Dihydroniphimycin. New Polyol Macrolide Antibiotic Produced by Streptomyces hygroscopicus 15 Isolation and Structure Elucidation.
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منابع مشابه
Malonyl-4,5-dihydroniphimycin: A New Polyol Macrolide Antibiotic, Produced by Streptomyces hygroscopicus
Malonyl-4,5-dihydroniphimycin was isolated as a new antibiotic from the mycelium of Streptomyces hygroscopicus 15. The chemical constitution was elucidated from the physico-chemical properties, using NMR techniques and mass spectrometry, to be a 36-membered macrolide related to non-polyenic antibiotics. Malonyl-4,5-dihydroniphimycin displays activity against filamentous fungi and Gram-positive ...
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liters of the production medium consisting of glucose 1.0%, soybeanmeal 1.0%,NaCl0.5% andCaCO3 0.1%, pH 7.0 before autoclaving. After 120 hours of cultivation at 30°C, the culture broth (4.0 liters) was centrifuged. The mycelium was extracted three times with MeOH,while the filtrate with ?7-BuOH.The active solvent extracts were combinedand evaporated to dryness in vacuo. The crude products were...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2000
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.53.627